Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 11/20 | 1.00 |
| ▸ | PLK1 | P53350 | 11/20 | 0.86 |
| ▸ | PLK4 | O00444 | 2/20 | 0.65 |
| ▸ | AURKA | O14965 | 2/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | LCK | P06239 | 2/20 | 0.65 |
| ▸ | CSF1R | P07333 | 2/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.65 |
| ▸ | SRC | P12931 | 2/20 | 0.65 |
| ▸ | FLT1 | P17948 | 2/20 | 0.65 |
| ▸ | CDK2 | P24941 | 2/20 | 0.65 |
| ▸ | AXL | P30530 | 2/20 | 0.65 |
| ▸ | FLT4 | P35916 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 2/20 | 0.65 |
| ▸ | GSK3B | P49841 | 2/20 | 0.65 |
| ▸ | NEK2 | P51955 | 2/20 | 0.65 |
| ▸ | JAK3 | P52333 | 2/20 | 0.65 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.65 |
| ▸ | STK3 | Q13188 | 2/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038453 | 0.93 | IKBKE (1.00) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL4033240 | 0.86 | IKBKE (1.00) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL4034598 | 0.85 | PLK1 (0.88) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL4032804 | 0.82 | IKBKE (0.80) | IKBKEPLK1PLK3TBK1 | |
| SCHEMBL4033041 | 0.82 | IKBKE (0.79) | IKBKEPLK1PLK4AURKAJAK2 | |
| Gsk-1030058A SCHEMBL5058261 | 0.80 | PLK1 (0.87) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL5062053 | 0.79 | PLK1 (0.77) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL5062302 | 0.79 | PLK1 (0.74) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL5058278 | 0.79 | PLK1 (1.00) | IKBKEPLK1PLK4AURKAJAK2 | |
| SCHEMBL14050183 | 0.79 | IKBKE (0.65) | IKBKEPLK1PLK4AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720864-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LTD (GB) | 2009-05-06 | — | — | EP | claimed |
| EP-1720864-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LTD (GB) | 2009-05-06 | — | — | EP | disclosed |
| US-20070149519-A1 | Benzimidazol substituted thiopene derivatives with activity on ikk3 | GLAXO GROUP LIMITED (GB) | 2007-06-28 | — | — | US | disclosed |
| US-20070149519-A1 | Benzimidazol substituted thiopene derivatives with activity on ikk3 | GLAXO GROUP LIMITED (GB) | 2007-06-28 | — | — | US | disclosed |
| US-20070149519-A1 | Benzimidazol substituted thiopene derivatives with activity on ikk3 | GLAXO GROUP LIMITED (GB) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149519-A1 | Benzimidazol substituted thiopene derivatives with activity on ikk3 | IKBKE, IKBKB, TBK1 | IKBKE 1/4885PLK1 1088/4885PLK4 930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.