Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 10/20 | 0.46 |
| ▸ | PLK1 | P53350 | 9/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037455 | 0.80 | IKBKE (0.40) | IKBKEPLK1SRCFGFR1TBK1 | |
| SCHEMBL4034530 | 0.80 | IKBKE (0.41) | IKBKEPLK1PLK3CDK2SRC | |
| SCHEMBL4038336 | 0.79 | IKBKE (0.57) | IKBKEPLK1PLK3CDK2SRC | |
| SCHEMBL4032684 | 0.76 | FGFR1 (0.43) | IKBKEPLK1SRCFGFR1TBK1 | |
| SCHEMBL4034367 | 0.76 | PLK1 (0.44) | IKBKEPLK1SRCFGFR1TBK1 | |
| SCHEMBL4040575 | 0.74 | IKBKE (0.40) | IKBKEPLK1SRCFGFR1TBK1 | |
| SCHEMBL4033246 | 0.73 | IKBKE (0.77) | IKBKEPLK1PLK3CDK2TBK1 | |
| SCHEMBL4032649 | 0.73 | IKBKE (0.39) | IKBKEPLK1SRCFGFR1TBK1 | |
| SCHEMBL4035304 | 0.73 | PLK1 (0.46) | IKBKEPLK1SRCFGFR1TBK1 | |
| SCHEMBL4036831 | 0.73 | PLK1 (0.46) | IKBKEPLK1SRCFGFR1TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720864-B1 | BENZIMIDAZOL SUBSTITUTED THIOPHENE DERIVATIVES WITH ACTIVITY ON IKK3 | GLAXO GROUP LTD (GB) | 2009-05-06 | — | — | EP | claimed |