Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.55 |
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033268 | 0.83 | SIGMAR1 (0.52) | SIGMAR1CCR3KMT2AMEN1NPC1 | |
| SCHEMBL5832503 | 0.78 | CCR3 (0.60) | SIGMAR1CCR3KMT2AMEN1NPC1 | |
| SCHEMBL8035527 | 0.71 | SIGMAR1 (1.00) | SIGMAR1NPC1 | |
| SCHEMBL8023923 | 0.71 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL6993451 | 0.71 | SIGMAR1 (0.67) | SIGMAR1 | |
| SCHEMBL5833095 | 0.71 | CCR3 (0.58) | SIGMAR1CCR3KMT2AMEN1NPC1 | |
| SCHEMBL5743274 | 0.70 | SIGMAR1 (0.59) | SIGMAR1CCR3POLBKMT2AMEN1 | |
| SCHEMBL18840775 | 0.70 | CCR3 (1.00) | CCR3 | |
| SCHEMBL3937233 | 0.70 | MEN1 (0.60) | SIGMAR1KMT2AMEN1 | |
| SCHEMBL8033644 | 0.70 | SIGMAR1 (1.00) | SIGMAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212299-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2009-04-08 | — | — | EP | claimed |