Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.46 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.46 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.46 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.46 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16879817 | 0.81 | NPC1 (0.49) | POLBSMN1; SMN2CYP2C9EPHX1NPC1 | |
| SCHEMBL29050657 | 0.80 | POLB (0.61) | POLBSMN1; SMN2CYP2C9EPHX1NPC1 | |
| SCHEMBL1004510 | 0.79 | NPC1 (0.50) | POLBSMN1; SMN2CYP2C9EPHX1NPC1 | |
| SCHEMBL408310 | 0.78 | CYP2C9 (0.67) | POLBSMN1; SMN2CYP2C9EPHX1NPC1 | |
| SCHEMBL118008 | 0.78 | HDAC3 (0.54) | POLBSMN1; SMN2CYP2C9EPHX1NPC1 | |
| SCHEMBL18455144 | 0.77 | SMN1; SMN2 (0.51) | POLBSMN1; SMN2CYP2C9EPHX1NPC1 | |
| SCHEMBL12024336 | 0.77 | POLB (0.62) | POLBSMN1; SMN2CYP2C9EPHX1NPC1 | |
| Acetic Acid SCHEMBL6202098 | 0.77 | POLB (0.53) | POLBSMN1; SMN2CYP2C9EPHX1NPC1 | |
| SCHEMBL10504078 | 0.77 | POLB (0.58) | POLBSMN1; SMN2CYP2C9EPHX1NPC1 | |
| SCHEMBL7635937 | 0.76 | POLB (0.57) | POLBSMN1; SMN2CYP2C9EPHX1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029540-A2 | BENZAMIDE DERIVATIVES AND USES RELATED THERETO | Amgen Inc. (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007145834-A2 | BENZAMIDE DERIVATIVES AND USES RELATED THERETO | AMGEN INC. (US) | 2007-12-21 | — | — | WO | disclosed |