Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL408310 | 0.84 | CYP2C9 (0.67) | POLBCYP2C9SMN1; SMN2EPHX1HDAC3 | |
| SCHEMBL10504078 | 0.83 | POLB (0.58) | POLBCYP2C9SMN1; SMN2EPHX1HDAC3 | |
| Fluoride SCHEMBL2310518 | 0.83 | CYP2C9 (0.65) | POLBCYP2C9SMN1; SMN2EPHX1HDAC3 | |
| SCHEMBL28820732 | 0.83 | POLB (0.61) | POLBCYP2C9SMN1; SMN2EPHX1HDAC3 | |
| Bromide SCHEMBL6851253 | 0.83 | CYP2C9 (0.65) | POLBCYP2C9SMN1; SMN2EPHX1HDAC3 | |
| Hydrochloric Acid SCHEMBL22076570 | 0.83 | CYP2C9 (0.65) | POLBCYP2C9SMN1; SMN2EPHX1HDAC3 | |
| SCHEMBL29201540 | 0.83 | CYP2C9 (0.65) | POLBCYP2C9SMN1; SMN2EPHX1HDAC3 | |
| SCHEMBL13416406 | 0.82 | ALOX15 (0.56) | POLBCYP2C9SMN1; SMN2EPHX1HDAC3 | |
| SCHEMBL9359968 | 0.82 | POLB (0.56) | POLBCYP2C9SMN1; SMN2EPHX1HDAC3 | |
| SCHEMBL343830 | 0.81 | POLB (0.65) | POLBCYP2C9SMN1; SMN2EPHX1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116589467-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligands and methods of use thereof | 百济神州有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-116589466-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligands and methods of use thereof | 百济神州有限公司 | 2023-08-15 | — | — | CN | disclosed |