Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 5/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485667 | 0.85 | MEN1 (0.43) | MEN1KMT2AMCHR1SIGMAR1SMN1; SMN2 | |
| SCHEMBL4040765 | 0.76 | MEN1 (0.48) | MEN1KMT2AMCHR1SIGMAR1DCPS | |
| SCHEMBL6312412 | 0.74 | MEN1 (0.46) | MEN1KMT2AMCHR1SIGMAR1DCPS | |
| SCHEMBL7491507 | 0.74 | MEN1 (0.58) | MEN1KMT2AMCHR1SIGMAR1SMN1; SMN2 | |
| SCHEMBL13888608 | 0.74 | MEN1 (0.58) | MEN1KMT2AMCHR1SIGMAR1SMN1; SMN2 | |
| SCHEMBL6312769 | 0.71 | MEN1 (0.58) | MEN1KMT2AMCHR1SIGMAR1SMN1; SMN2 | |
| SCHEMBL4033625 | 0.70 | MEN1 (0.43) | MEN1KMT2AMCHR1SIGMAR1DCPS | |
| SCHEMBL4033461 | 0.70 | ACHE (0.51) | MEN1KMT2AMCHR1SIGMAR1SMN1; SMN2 | |
| SCHEMBL4034063 | 0.70 | MEN1 (0.66) | MEN1KMT2AMCHR1SIGMAR1SMN1; SMN2 | |
| SCHEMBL4036032 | 0.70 | ACHE (0.62) | MEN1KMT2ASIGMAR1SMN1; SMN2CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212299-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2009-04-08 | — | — | EP | disclosed |