Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.67 |
| ▸ | CCR1 | P32246 | 2/20 | 0.60 |
| ▸ | CCR3 | P51677 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032289 | 0.85 | SIGMAR1 (0.70) | SIGMAR1CCR1CCR3MEN1KMT2A | |
| SCHEMBL12511823 | 0.84 | CCR3 (0.53) | SIGMAR1CCR1CCR3MEN1KMT2A | |
| SCHEMBL2210918 | 0.82 | UTS2R (0.49) | SIGMAR1CCR1CCR3MEN1KMT2A | |
| SCHEMBL4036818 | 0.80 | SIGMAR1 (0.67) | SIGMAR1CCR1CCR3MEN1KMT2A | |
| SCHEMBL2214628 | 0.79 | SIGMAR1 (0.58) | SIGMAR1CCR1CCR3MEN1KMT2A | |
| SCHEMBL2247064 | 0.79 | SIGMAR1 (0.46) | SIGMAR1CCR1CCR3MEN1KMT2A | |
| SCHEMBL2214629 | 0.79 | SIGMAR1 (0.58) | SIGMAR1CCR1CCR3MEN1KMT2A | |
| SCHEMBL6329318 | 0.79 | SIGMAR1 (0.65) | SIGMAR1CCR1CCR3MEN1KMT2A | |
| SCHEMBL12511619 | 0.78 | SIGMAR1 (0.47) | SIGMAR1CCR1CCR3MEN1KMT2A | |
| SCHEMBL2210708 | 0.78 | CCR3 (0.68) | SIGMAR1CCR1CCR3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212299-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2009-04-08 | — | — | EP | claimed |
| EP-1212299-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2009-04-08 | — | — | EP | disclosed |