Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | CCR1 | P32246 | 1/20 | 0.57 |
| ▸ | CCR3 | P51677 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6329318 | 0.87 | SIGMAR1 (0.65) | SIGMAR1MEN1KMT2ACCR1CCR3 | |
| SCHEMBL4033740 | 0.85 | SIGMAR1 (0.67) | SIGMAR1MEN1KMT2ACCR1CCR3 | |
| SCHEMBL4031563 | 0.84 | SIGMAR1 (0.55) | SIGMAR1MEN1KMT2ACCR1CCR3 | |
| SCHEMBL7091986 | 0.84 | SIGMAR1 (0.60) | SIGMAR1MEN1KMT2ACCR1CCR3 | |
| SCHEMBL4036818 | 0.81 | SIGMAR1 (0.67) | SIGMAR1MEN1KMT2ACCR1CCR3 | |
| SCHEMBL4023538 | 0.80 | CCR3 (0.53) | SIGMAR1CCR3DRD2DRD4DRD3 | |
| SCHEMBL6386061 | 0.79 | SIGMAR1 (0.54) | SIGMAR1MEN1KMT2ACCR1CCR3 | |
| SCHEMBL4036340 | 0.79 | SIGMAR1 (0.68) | SIGMAR1MEN1KMT2ACCR1CCR3 | |
| SCHEMBL4031255 | 0.78 | SIGMAR1 (0.68) | SIGMAR1MEN1KMT2ACCR1CCR3 | |
| SCHEMBL5592604 | 0.77 | SIGMAR1 (0.62) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212299-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2009-04-08 | — | — | EP | claimed |
| EP-1212299-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2009-04-08 | — | — | EP | disclosed |