Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 2/20 | 0.43 |
| ▸ | FEN1 | P39748 | 2/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025292 | 0.85 | ERCC1 (0.48) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL4028670 | 0.83 | ALDH1A1 (0.50) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL4029715 | 0.83 | ERCC1 (0.63) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL4032043 | 0.79 | ERCC1 (0.67) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL4029729 | 0.78 | MAPT (0.47) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL4025290 | 0.68 | ERCC1 (0.71) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL4028669 | 0.66 | FEN1 (0.65) | ERCC1FEN1ERCC4ALDH1A1KDM4E | |
| SCHEMBL11858866 | 0.61 | ALDH1A1 (0.39) | ALDH1A1KDM4EHPGDPOLBLMNA | |
| SCHEMBL11863646 | 0.61 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDPOLBLMNA | |
| SCHEMBL4027681 | 0.61 | ERCC1 (0.41) | ERCC1FEN1ERCC4ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022199-A1 | CYANOTRIAZOLE COMPOUNDS | Otsuka Pharmaceutical Co., Ltd. (JP) | 2016-05-25 | — | — | EP | claimed |
| WO-2015008872-A1 | CYANOTRIAZOLE COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-01-22 | — | — | WO | claimed |
| WO-2009016216-A1 | TRIAZOLE DERIVATIVES AS SCD INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-05 | — | — | WO | claimed |
| CN-101918395-A | Triazole oxadiazole derivatives | MERCK SERONO SA | 2010-12-15 | — | — | CN | disclosed |
| CN-101558066-A | Pyrrole derivatives with antibacterial activity | ASTRAZENECA AB (SE) | 2009-10-14 | — | — | CN | disclosed |
| WO-2009016216-A1 | TRIAZOLE DERIVATIVES AS SCD INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |
| CN-100390169-C | Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents | ASTRAZENECA AB (SE) | 2008-05-28 | — | — | CN | disclosed |
| CN-1753888-A | Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents | ASTRAZENECA AB (SE) | 2006-03-29 | — | — | CN | disclosed |
| CN-1742015-A | Oxazolidinone and / or isoxazoline derivatives as antibacterial agents | ASTRAZENECA AB (SE) | 2006-03-01 | — | — | CN | disclosed |
| CN-1227229-C | Ethylene derivatives and pesticides containing the same | NISSAN CHEMICAL IND LTD (JP) | 2005-11-16 | — | — | CN | disclosed |
| CN-1216530-A | Ethylene derivatives and pesticides containing the same | NISSAN CHEMICAL IND LTD (JP) | 1999-05-12 | — | — | CN | disclosed |