Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 3/20 | 0.67 |
| ▸ | FEN1 | P39748 | 3/20 | 0.67 |
| ▸ | ERCC4 | Q92889 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025292 | 0.84 | ERCC1 (0.48) | ERCC1FEN1ERCC4KDM4EALDH1A1 | |
| SCHEMBL4032042 | 0.81 | ERCC1 (1.00) | ERCC1FEN1ERCC4KDM4EALDH1A1 | |
| SCHEMBL4028670 | 0.80 | ALDH1A1 (0.50) | ERCC1FEN1ERCC4KDM4EALDH1A1 | |
| SCHEMBL4033752 | 0.79 | ERCC1 (0.43) | ERCC1FEN1ERCC4KDM4EALDH1A1 | |
| SCHEMBL4029257 | 0.78 | FEN1 (0.44) | ERCC1FEN1ERCC4KDM4EALDH1A1 | |
| SCHEMBL4027681 | 0.78 | ERCC1 (0.41) | ERCC1FEN1ERCC4ALDH1A1NPC1 | |
| SCHEMBL4027881 | 0.78 | ERCC1 (0.40) | ERCC1FEN1ERCC4KDM4EALDH1A1 | |
| SCHEMBL4028118 | 0.78 | ERCC1 (0.40) | ERCC1FEN1ERCC4KDM4EALDH1A1 | |
| SCHEMBL4029729 | 0.77 | MAPT (0.47) | ERCC1FEN1ERCC4KDM4EALDH1A1 | |
| SCHEMBL4031571 | 0.76 | ERCC1 (0.40) | ERCC1FEN1ERCC4ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-B1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-01-07 | — | — | EP | claimed |