Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028916 | 0.89 | GAA (0.45) | MAPTNPSR1LMNAALDH1A1GAA | |
| SCHEMBL4029082 | 0.89 | GAA (0.45) | MAPTNPSR1LMNAALDH1A1GAA | |
| SCHEMBL4029400 | 0.88 | ALDH1A1 (0.43) | MAPTNPSR1LMNAALDH1A1GAA | |
| SCHEMBL4034254 | 0.86 | KMT2A (0.44) | MAPTNPSR1LMNAALDH1A1GAA | |
| SCHEMBL4034300 | 0.85 | LPAR1 (0.41) | MAPK1MAPTNPSR1TDP1LMNA | |
| SCHEMBL15437794 | 0.85 | LPAR1 (0.41) | MAPK1MAPTNPSR1TDP1LMNA | |
| SCHEMBL4033798 | 0.84 | MEN1 (0.43) | MAPTNPSR1LMNAALDH1A1GAA | |
| SCHEMBL4027632 | 0.82 | LPAR1 (0.39) | MAPK1MAPTNPSR1TDP1LMNA | |
| SCHEMBL4027629 | 0.82 | LPAR1 (0.39) | MAPK1MAPTNPSR1TDP1LMNA | |
| SCHEMBL4037102 | 0.81 | GPBAR1 (0.49) | MAPTNPSR1LMNAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |