SCHEMBL4033836

SCHEMBL4033836

COc1ccccc1-c1ccc(-c2c[nH]c(CCNC(=O)O)n2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 2/20 0.46
HIF1A Q16665 1/20 0.43
ADORA3 P0DMS8 1/20 0.42
PPARG P37231 1/20 0.42
PPARA Q07869 1/20 0.42
CDK4 P11802 2/20 0.41
CCND1 P24385 2/20 0.41
ABL1 P00519 3/20 0.41
VCP P55072 1/20 0.41
NPC1 O15118 1/20 0.41
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
GAA P10253 1/20 0.41
MAPT P10636 1/20 0.41
THRB P10828 1/20 0.41
HPGD P15428 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ROCK2 O75116 2/20 0.40
ROCK1 Q13464 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14736555 0.91 CDK4 (0.44) ADORA3CDK4CCND1NPC1ALDH1A1
SCHEMBL1927752 0.84 KDM4E (0.46) DHODHHIF1AADORA3CDK4CCND1
SCHEMBL4041638 0.84 HDAC3 (0.45) CDK4CCND1ALDH1A1LMNAMAPT
SCHEMBL2338147 0.84 LTA4H (0.42) HIF1ACDK4CCND1ALDH1A1MAPT
SCHEMBL14736459 0.83 CYP3A4 (0.43) HIF1ACDK4CCND1ALDH1A1LMNA
SCHEMBL4041262 0.83 HIF1A (0.43) DHODHHIF1AADORA3PPARGPPARA
SCHEMBL4034076 0.83 LMNA (0.37) CDK4CCND1ABL1ALDH1A1LMNA
SCHEMBL4036430 0.83 SCN9A (0.40) HIF1AABL1VCPNPC1ALDH1A1
SCHEMBL2342304 0.81 LTA4H (0.47)
SCHEMBL2340396 0.80 MEN1 (0.41) CDK4CCND1NPC1LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1379514-B1 5-MEMBERED HETEROCYCLES, PREPARATION AND APPLICATION THEREOF AS MEDICAMENTS IPSEN PHARMA (FR) 2009-07-15 EP claimed
EP-1379514-A2 5-MEMBERED HETEROCYCLES, PREPARATION AND APPLICATION THEREOF AS MEDICAMENTS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2004-01-14 EP claimed
WO-2002083656-A2 5-MEMBERED HETEROCYCLES, PREPARATION AND USE THEREOF AS MAO INHIBITORS AND LIPID PEROXIDATION INHIBITORS, PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2002-10-24 WO claimed
EP-1379514-B1 5-MEMBERED HETEROCYCLES, PREPARATION AND APPLICATION THEREOF AS MEDICAMENTS IPSEN PHARMA (FR) 2009-07-15 EP disclosed
EP-1379514-A2 5-MEMBERED HETEROCYCLES, PREPARATION AND APPLICATION THEREOF AS MEDICAMENTS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2004-01-14 EP disclosed
WO-2002083656-A2 5-MEMBERED HETEROCYCLES, PREPARATION AND USE THEREOF AS MAO INHIBITORS AND LIPID PEROXIDATION INHIBITORS, PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2002-10-24 WO disclosed