Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184408 | 0.75 | PPARG (0.69) | PPARGRARGRXRA | |
| SCHEMBL6891679 | 0.75 | PPARG (0.64) | PPARGRARGRXRAALDH1A1KDM4E | |
| SCHEMBL2085262 | 0.72 | MAPT (0.40) | PPARGALDH1A1KDM4EMAPTHTT | |
| SCHEMBL4500673 | 0.66 | CYP2D6 (0.47) | LIPEALDH1A1KDM4EHTTCYP2D6 | |
| SCHEMBL85721 | 0.65 | CYP2D6 (0.55) | LIPEALDH1A1KDM4ECYP2D6CYP2C19 | |
| SCHEMBL4953723 | 0.65 | POLB (0.44) | PPARGLIPEALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL4953717 | 0.65 | POLB (0.44) | PPARGLIPEALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL8803105 | 0.64 | POLB (0.43) | LIPEALDH1A1HTTCYP2D6CYP2C19 | |
| Rosiglitazone SCHEMBL7052472 | 0.63 | PPARG (1.00) | PPARGRARGRXRAALDH1A1KDM4E | |
| SCHEMBL15348621 | 0.63 | PPARG (0.79) | PPARGRARGRXRAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032569-A1 | PROCESS FOR THE SYNTHESIS OF BENZYLIDENE ROSIGLITAZONE BASE | Richter Gedeon NYRT (HU) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007148141-A1 | PROCESS FOR THE SYNTHESIS OF BENZYLIDENE ROSIGLITAZONE BASE | RICHTER GEDEON NYRT. (HU) | 2007-12-27 | — | — | WO | disclosed |