Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 6/20 | 0.49 |
| ▸ | FLT1 | P17948 | 4/20 | 0.49 |
| ▸ | KIT | P10721 | 11/20 | 0.48 |
| ▸ | BRAF | P15056 | 10/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624730 | 0.93 | JAK2 (0.61) | NPC1RAB9AJAK2JAK1KDR | |
| SCHEMBL4042755 | 0.92 | NPC1 (0.52) | NPC1HPGDRAB9ASMN1; SMN2JAK2 | |
| SCHEMBL4034467 | 0.86 | NPC1 (0.55) | NPC1HPGDRAB9ASMN1; SMN2JAK2 | |
| SCHEMBL3876110 | 0.85 | NPC1 (0.56) | NPC1HPGDRAB9ASMN1; SMN2JAK2 | |
| SCHEMBL6543870 | 0.84 | KIT (0.63) | NPC1HPGDRAB9ASMN1; SMN2JAK2 | |
| SCHEMBL4032272 | 0.83 | KIT (0.47) | KDRFLT1KITBRAF | |
| SCHEMBL4036551 | 0.80 | KIT (0.48) | KDRFLT1KITBRAF | |
| SCHEMBL4040691 | 0.79 | JAK3 (0.51) | KITBRAFJAK3IRAK4 | |
| SCHEMBL6543933 | 0.79 | JAK2 (0.64) | NPC1RAB9AJAK2JAK1KDR | |
| SCHEMBL4036769 | 0.79 | FLT1 (0.48) | KDRFLT1KITBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392680-B1 | SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 | BAYER SCHERING PHARMA AG (DE) | 2009-07-22 | — | — | EP | disclosed |
| EP-1392680-A2 | SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002090352-A2 | SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-11-14 | — | — | WO | disclosed |