Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 9/20 | 0.50 |
| ▸ | BRAF | P15056 | 9/20 | 0.50 |
| ▸ | KDR | P35968 | 7/20 | 0.49 |
| ▸ | FLT1 | P17948 | 3/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034472 | 0.92 | NPC1 (0.52) | NPC1HPGDRAB9ASMN1; SMN2JAK2 | |
| SCHEMBL6543870 | 0.87 | KIT (0.63) | NPC1HPGDRAB9ASMN1; SMN2JAK2 | |
| SCHEMBL6624730 | 0.85 | JAK2 (0.61) | NPC1RAB9AJAK2JAK1KIT | |
| SCHEMBL3876110 | 0.85 | NPC1 (0.56) | NPC1HPGDRAB9ASMN1; SMN2JAK2 | |
| SCHEMBL4034467 | 0.84 | NPC1 (0.55) | NPC1HPGDRAB9ASMN1; SMN2JAK2 | |
| SCHEMBL4035614 | 0.83 | KIT (0.51) | KITBRAFKDRFLT1 | |
| SCHEMBL4037571 | 0.81 | KIT (0.50) | KITBRAFKDRFLT1 | |
| SCHEMBL6612511 | 0.80 | JAK3 (0.53) | KITBRAF | |
| SCHEMBL3868951 | 0.79 | JAK2 (0.66) | NPC1RAB9AJAK2JAK1KIT | |
| SCHEMBL3869371 | 0.78 | JAK2 (0.66) | NPC1RAB9AJAK2JAK1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392680-B1 | SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 | BAYER SCHERING PHARMA AG (DE) | 2009-07-22 | — | — | EP | disclosed |
| EP-1392680-A2 | SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002090352-A2 | SELECTIVE ANTHRANILAMIDE PYRIDINE AMIDES AS INHIBITORS OF VEGFR-2 AND VEGFR-3 | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-11-14 | — | — | WO | disclosed |