Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3333404 | 0.87 | MAPT (0.81) | MAPTNPSR1RXFP1ADORA1KDM4E | |
| SCHEMBL245593 | 0.84 | ADORA1 (0.64) | MAPTNPSR1RXFP1ADORA1KDM4E | |
| SCHEMBL241556 | 0.81 | MAPT (0.59) | MAPTNPSR1RXFP1ADORA1KDM4E | |
| SCHEMBL244863 | 0.81 | ADORA1 (0.61) | MAPTNPSR1RXFP1ADORA1KDM4E | |
| SCHEMBL13938147 | 0.81 | ADORA1 (0.62) | MAPTNPSR1RXFP1ADORA1KDM4E | |
| SCHEMBL15286658 | 0.81 | ADORA1 (0.64) | MAPTNPSR1RXFP1ADORA1KDM4E | |
| SCHEMBL28185531 | 0.77 | KDM4E (0.73) | MAPTNPSR1RXFP1ADORA1KDM4E | |
| SCHEMBL6462984 | 0.77 | MAPT (0.59) | MAPTNPSR1RXFP1ADORA1KDM4E | |
| SCHEMBL3556602 | 0.76 | ADORA2B (0.68) | MAPTNPSR1RXFP1ADORA1KDM4E | |
| SCHEMBL923745 | 0.76 | MAPT (0.52) | MAPTNPSR1RXFP1ADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040992-A1 | Substituted 2, 6-Diamino-3, 5-Dicyano-4-Aryl-Pyridines And Their Use As Adenosine-Receptor-Selective Ligands | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-02-14 | — | — | US | disclosed |
| US-20130040992-A1 | Substituted 2, 6-Diamino-3, 5-Dicyano-4-Aryl-Pyridines And Their Use As Adenosine-Receptor-Selective Ligands | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-02-14 | — | — | US | disclosed |
| US-20130040992-A1 | Substituted 2, 6-Diamino-3, 5-Dicyano-4-Aryl-Pyridines And Their Use As Adenosine-Receptor-Selective Ligands | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-02-14 | — | — | US | disclosed |
| US-8242281-B2 | Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-08-14 | — | — | US | disclosed |
| US-8242281-B2 | Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-08-14 | — | — | US | disclosed |
| US-8242281-B2 | Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-08-14 | — | — | US | disclosed |
| EP-1373265-B1 | SUBSTITUTED 2,6-DIAMINO-3,5-DICYANO-4-ARYL-PYRIDINES AND THEIR USE AS ADENOSINE RECEPTOR-SELECTIVE LIGANDS | BAYER HEALTHCARE AG (DE) | 2009-05-06 | — | — | EP | disclosed |
| US-20070213372-A1 | Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands | BAYER AKTIENGESELLSCHAFT (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213372-A1 | Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands | BAYER AKTIENGESELLSCHAFT (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213372-A1 | Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands | BAYER AKTIENGESELLSCHAFT (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20040162427-A1 | Substituted 2,6-diamino-3,5-dicyano-4-aryl-pyridines and their use as adenosine receptor-selective ligands | BAYER AKTIENGESELLSCHAFT (DE) | 2004-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162427-A1 | Substituted 2,6-diamino-3,5-dicyano-4-aryl-pyridines and their use as adenosine receptor-selective ligands | ADORA2A, ADORA3, ADORA1 | MAPT 4364/4885NPSR1 81/4885RXFP1 353/4885 |
| US-20130040992-A1 | Substituted 2, 6-Diamino-3, 5-Dicyano-4-Aryl-Pyridines And Their Use As Adenosine-Receptor-Selective Ligands | ADORA3, ADORA1, ADORA2A | MAPT 4350/4885NPSR1 264/4885RXFP1 355/4885 |
| US-20070213372-A1 | Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands | ADORA3, ADORA1, ADORA2A | MAPT 4461/4885NPSR1 272/4885RXFP1 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.