Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 15/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CCR5 | P51681 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL438264 | 1.00 | CCR1 (1.00) | CCR1CHRM2CCR5NR1I2HRH1 | |
| SCHEMBL653493 | 1.00 | CCR1 (1.00) | CCR1CHRM2CCR5NR1I2HRH1 | |
| SCHEMBL12121747 | 1.00 | CCR1 (1.00) | CCR1CHRM2CCR5NR1I2HRH1 | |
| SCHEMBL438487 | 1.00 | CCR1 (1.00) | CCR1CHRM2CCR5NR1I2HRH1 | |
| SCHEMBL438265 | 1.00 | CCR1 (1.00) | CCR1CHRM2CCR5NR1I2HRH1 | |
| SCHEMBL653494 | 1.00 | CCR1 (1.00) | CCR1CHRM2CCR5NR1I2HRH1 | |
| SCHEMBL438488 | 1.00 | CCR1 (1.00) | CCR1CHRM2CCR5NR1I2HRH1 | |
| SCHEMBL29395513 | 1.00 | CCR1 (1.00) | CCR1CHRM2CCR5NR1I2HRH1 | |
| SCHEMBL13620905 | 1.00 | CCR1 (1.00) | CCR1CHRM2CCR5NR1I2HRH1 | |
| SCHEMBL10287989 | 0.95 | CCR1 (0.91) | CCR1CHRM2CCR5HRH1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481737-B2 | Solid forms of a chemokine receptor antagonist and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481737-B2 | Solid forms of a chemokine receptor antagonist and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20130040979-A1 | CCR1 INHIBITORS USEFUL FOR THE TREAMENT OF MULTIPLE MYELOMA AND OTHER DISORDERS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040979-A1 | CCR1 INHIBITORS USEFUL FOR THE TREAMENT OF MULTIPLE MYELOMA AND OTHER DISORDERS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040979-A1 | CCR1 INHIBITORS USEFUL FOR THE TREAMENT OF MULTIPLE MYELOMA AND OTHER DISORDERS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20120065223-A1 | SOLID FORMS OF A CHEMOKINE RECEPTOR ANTAGONIST AND METHODS OF USE THEREOF | NEVES CAROLE (FR) | 2012-03-15 | — | — | US | disclosed |
| US-7960549-B2 | Solid forms of a chemokine receptor antagonist and methods of use thereof | NEVES CAROLE | 2011-06-14 | — | — | US | disclosed |
| US-20110021777-A1 | PROCESS IMPROVEMENT | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-20110021777-A1 | PROCESS IMPROVEMENT | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-20100280247-A1 | PROCESS IMPROVEMENT USING TMEDA | MILLENNIUM PHARMACEUTICALS INC. (US) | 2010-11-04 | — | — | US | disclosed |
| US-20100280247-A1 | PROCESS IMPROVEMENT USING TMEDA | MILLENNIUM PHARMACEUTICALS INC. (US) | 2010-11-04 | — | — | US | disclosed |
| US-20090286823-A1 | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders | MILLENNIUM PHARMACEUTICALS INC. (US) | 2009-11-19 | — | — | US | disclosed |
| US-20090286823-A1 | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders | MILLENNIUM PHARMACEUTICALS INC. (US) | 2009-11-19 | — | — | US | disclosed |
| WO-2009073462-A1 | PROCESS FOR THE PREPARATION OF 5-CYCLOPROPYL-5, 11-DIHYDRO (1) BENZOXEPINO (3, 4-B) -PYRIDIN-5-OL USING TMEDA | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009070556-A1 | PROCESS IMPROVEMENT | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-04 | — | — | WO | disclosed |
| US-20070010545-A1 | Solid forms of a chemokine receptor antagonist and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021777-A1 | PROCESS IMPROVEMENT | PARP3, BRD3, CYP4F3 | CCR1 4394/4885CHRM2 4334/4885CCR5 3479/4885 |
| US-20090286823-A1 | CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders | CCR1, CCR3, CCR4 | CCR1 1/4885CHRM2 4457/4885CCR5 12/4885 |
| US-20100280247-A1 | PROCESS IMPROVEMENT USING TMEDA | TMED7, TMED9, TMED2 | CCR1 4542/4885CHRM2 4855/4885CCR5 4632/4885 |
| US-20120065223-A1 | SOLID FORMS OF A CHEMOKINE RECEPTOR ANTAGONIST AND METHODS OF USE THEREOF | CCR1, CXCR1, CCR5 | CCR1 1/4885CHRM2 690/4885CCR5 3/4885 |
| US-20070010545-A1 | Solid forms of a chemokine receptor antagonist and methods of use thereof | CCR1, CXCR1, CCR5 | CCR1 1/4885CHRM2 690/4885CCR5 3/4885 |
| US-20130040979-A1 | CCR1 INHIBITORS USEFUL FOR THE TREAMENT OF MULTIPLE MYELOMA AND OTHER DISORDERS | CCR1, CCR3, CCR4 | CCR1 1/4885CHRM2 4696/4885CCR5 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.