Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.83 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034737 | 0.89 | SIGMAR1 (0.81) | SIGMAR1MEN1KMT2A | |
| SCHEMBL2213082 | 0.86 | SIGMAR1 (0.76) | SIGMAR1MEN1KMT2AMCHR1 | |
| SCHEMBL7487718 | 0.85 | SIGMAR1 (0.74) | SIGMAR1MEN1KMT2AMCHR1 | |
| SCHEMBL2212892 | 0.85 | SIGMAR1 (0.73) | SIGMAR1MEN1KMT2AMCHR1 | |
| SCHEMBL6312739 | 0.84 | SIGMAR1 (0.76) | SIGMAR1MEN1KMT2AMCHR1 | |
| SCHEMBL6327856 | 0.83 | SIGMAR1 (0.71) | SIGMAR1MEN1KMT2AMCHR1 | |
| SCHEMBL4034921 | 0.83 | MCHR1 (0.77) | SIGMAR1MEN1KMT2AMCHR1 | |
| SCHEMBL12511819 | 0.83 | SIGMAR1 (0.70) | SIGMAR1MEN1KMT2AMCHR1 | |
| SCHEMBL4976899 | 0.83 | SIGMAR1 (0.70) | SIGMAR1MEN1KMT2AMCHR1 | |
| SCHEMBL4036167 | 0.82 | SIGMAR1 (0.70) | SIGMAR1MEN1KMT2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212299-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2009-04-08 | — | — | EP | claimed |
| EP-1212299-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LTD (GB) | 2009-04-08 | — | — | EP | disclosed |
| US-6903085-B1 | Substituted piperidine compounds useful as modulators of chemokine receptor activity | ASTRAZENECA, AB (CH) | 2005-06-07 | — | — | US | disclosed |
| EP-1212299-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca UK Limited (GB) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014333-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA UK LIMITED (GB) | 2001-03-01 | — | — | WO | disclosed |