Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.64 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CCR1 | P32246 | 1/20 | 0.53 |
| ▸ | CCR3 | P51677 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975569 | 0.89 | SIGMAR1 (0.57) | SIGMAR1MEN1KMT2AMCHR1TEAD1 | |
| SCHEMBL6312739 | 0.88 | SIGMAR1 (0.76) | SIGMAR1MEN1KMT2AMCHR1SMN1; SMN2 | |
| SCHEMBL12511819 | 0.87 | SIGMAR1 (0.70) | SIGMAR1MEN1KMT2AMCHR1TEAD1 | |
| SCHEMBL4214471 | 0.86 | TEAD1 (0.73) | SIGMAR1MEN1KMT2AMCHR1TEAD1 | |
| SCHEMBL2213082 | 0.86 | SIGMAR1 (0.76) | SIGMAR1MEN1KMT2AMCHR1SMN1; SMN2 | |
| SCHEMBL7487718 | 0.85 | SIGMAR1 (0.74) | SIGMAR1MEN1KMT2AMCHR1SMN1; SMN2 | |
| SCHEMBL4034602 | 0.83 | SIGMAR1 (0.83) | SIGMAR1MEN1KMT2AMCHR1 | |
| SCHEMBL4039758 | 0.83 | KMT2A (0.65) | SIGMAR1MEN1KMT2AMCHR1SMN1; SMN2 | |
| SCHEMBL6327856 | 0.83 | SIGMAR1 (0.71) | SIGMAR1MEN1KMT2AMCHR1SMN1; SMN2 | |
| SCHEMBL28996046 | 0.82 | SIGMAR1 (0.74) | SIGMAR1KMT2AMCHR1MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994002-A1 | PIPERIDINE DERIVATIVES, THEIR PROCESS FOR PREPARATION, THEIR USE AS THERAPEUTIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007102767-A1 | PIPERIDINE DERIVATIVES, THEIR PROCESS FOR PREPARATION, THEIR USE AS THERAPEUTIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2007-09-13 | — | — | WO | disclosed |