Sugi Predict

Sugi Predict / Compounds / Pyridazine

Pyridazine

Pyridazine

SCHEMBL4034767

Fc1ccc(-c2cnnc(-c3ccccc3)c2)cc1-c1cccnc1.c1ccnnc1

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ GABRG2 P18507 20/20 0.54
▸ GABRB3 P28472 20/20 0.54
▸ GABRA5 P31644 20/20 0.54
▸ GABRA3 P34903 20/20 0.54
▸ GABRA1 P14867 14/20 0.53
▸ GABRA2 P47869 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2652941 0.96 GABRG2 (0.57) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL2652903 0.85 GABRG2 (0.55) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL2652630 0.82 GABRG2 (0.64) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL4855823 0.80 GABRG2 (0.72) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL2653299 0.80 GABRG2 (0.80) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL2653754 0.79 GABRG2 (0.84) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL2653411 0.79 GABRG2 (0.66) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL2653098 0.78 GABRG2 (0.53) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL2653947 0.76 GABRG2 (0.62) GABRG2GABRB3GABRA5GABRA3GABRA1
SCHEMBL2652462 0.74 GABRG2 (0.54) GABRG2GABRB3GABRA5GABRA3GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1532120-B1 PHENYLPYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS MERCK SHARP & DOHME (GB) 2009-01-14 — — EP disclosed