Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 9/20 | 0.72 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.72 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.72 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.72 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.72 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653411 | 0.95 | GABRG2 (0.66) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL23061396 | 0.88 | CYP2A6 (0.60) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL221868 | 0.85 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL4856668 | 0.84 | GABRG2 (0.81) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2652941 | 0.83 | GABRG2 (0.57) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL2653098 | 0.82 | GABRG2 (0.53) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| Pyridazine SCHEMBL4034767 | 0.80 | GABRG2 (0.54) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| Formaldehyde SCHEMBL27875050 | 0.79 | GABRG2 (0.88) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL20426097 | 0.78 | CYP19A1 (0.89) | CYP19A1CYP2A6ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL12148395 | 0.78 | CYP19A1 (0.82) | CYP19A1CYP2A6ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7381725-B2 | Pyridazine derivatives as ligands for GABA receptors | MERCK SHARP & DOHME LTD. (GB) | 2008-06-03 | — | — | US | claimed |
| US-20060148809-A1 | Pyridazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2006-07-06 | — | — | US | claimed |
| EP-1532136-A1 | PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2005-05-25 | — | — | EP | claimed |
| WO-2004014891-A1 | PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2004-02-19 | — | — | WO | claimed |
| US-7381725-B2 | Pyridazine derivatives as ligands for GABA receptors | MERCK SHARP & DOHME LTD. (GB) | 2008-06-03 | — | — | US | disclosed |
| US-20060148809-A1 | Pyridazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2006-07-06 | — | — | US | disclosed |
| EP-1532136-A1 | PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004014891-A1 | PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148809-A1 | Pyridazine derivatives as ligands for gaba receptors | GABRA5, GABRA3, GABRA2 | GABRG2 15/4885GABRB3 6/4885GABRA5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.