Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | FABP1 | P07148 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037109 | 0.85 | GAA (0.57) | GAAALDH1A1HPGDTP53THRB | |
| SCHEMBL4033096 | 0.84 | GAA (0.60) | GAAALDH1A1HPGDTP53HCRTR1 | |
| SCHEMBL1382942 | 0.83 | GAA (0.56) | GAAALDH1A1HPGDTP53THRB | |
| SCHEMBL4032554 | 0.82 | QPCT (0.47) | GAAALDH1A1HPGDTP53THRB | |
| SCHEMBL4034972 | 0.82 | QPCT (0.47) | GAAALDH1A1HPGDTP53THRB | |
| SCHEMBL4033581 | 0.82 | GAA (0.57) | GAAALDH1A1HPGDHCRTR1KMT2A | |
| SCHEMBL4032274 | 0.79 | GAA (0.55) | GAAALDH1A1HPGDTP53THRB | |
| SCHEMBL4210429 | 0.79 | GAA (0.53) | GAAALDH1A1HPGDTP53HCRTR1 | |
| SCHEMBL4032496 | 0.79 | ALDH1A1 (0.51) | GAAALDH1A1HPGDPOLBMAPT | |
| Trifluoroacetic Acid SCHEMBL4034617 | 0.79 | QPCT (0.44) | GAAALDH1A1HPGDTP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | disclosed |