SCHEMBL4034833

SCHEMBL4034833

CCOc1cccc2cc(C3(C(C(=O)NC4CCCCC4)C4CCCCC4)Nc4ccccc4N3)oc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 3/20 0.47
DRD2 P14416 4/20 0.42
ADORA2A P29274 3/20 0.42
ADORA2B P29275 1/20 0.42
ADORA1 P30542 2/20 0.41
GAA P10253 1/20 0.40
HRH3 Q9Y5N1 1/20 0.39
ALDH1A1 P00352 2/20 0.39
HPGD P15428 2/20 0.39
LMNA P02545 1/20 0.39
ALOX12 P18054 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CYP1A2 P05177 2/20 0.38
CYP3A4 P08684 2/20 0.38
CYP2C19 P33261 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPT P10636 1/20 0.38
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4044158 0.82 GAA (0.47) GAAALDH1A1HPGDLMNAALOX12
SCHEMBL4034516 0.73 HPGD (0.45) GAAALDH1A1HPGDSMN1; SMN2CYP1A2
SCHEMBL4039886 0.72 POLB (0.47) ALDH1A1HPGDRAB9ASMN1; SMN2MAPT
SCHEMBL4039869 0.72 HPGD (0.45) ALDH1A1HPGDLMNARAB9AKMT2A
SCHEMBL4044962 0.72 KMT2A (0.49) ALDH1A1HPGDSMN1; SMN2KDM4EMAPT
SCHEMBL4037071 0.72 EPHX1 (0.46) GAAALDH1A1LMNAALOX12RAB9A
SCHEMBL4034357 0.72 HPGD (0.43) CNR2ALDH1A1HPGDLMNARAB9A
SCHEMBL4037895 0.72 HPGD (0.43) CNR2ALDH1A1HPGDLMNARAB9A
SCHEMBL4036629 0.71 NPC1 (0.49) GAAALDH1A1RAB9ASMN1; SMN2KDM4E
SCHEMBL4036857 0.71 HPGD (0.43) GAAALDH1A1HPGDLMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2038259-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP claimed
WO-2008000643-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO claimed
EP-3043865-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) 2016-07-20 EP disclosed
WO-2015036442-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2015-03-19 WO disclosed
EP-2038259-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP disclosed
WO-2008000643-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO disclosed