Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034357 | 0.91 | HPGD (0.43) | HPGDALDH1A1L3MBTL1RAB9ALMNA | |
| SCHEMBL4037895 | 0.91 | HPGD (0.43) | HPGDALDH1A1L3MBTL1RAB9ALMNA | |
| SCHEMBL4034697 | 0.88 | MEN1 (0.48) | ALDH1A1L3MBTL1RAB9ANPC1MEN1 | |
| SCHEMBL1577410 | 0.88 | MEN1 (0.48) | ALDH1A1L3MBTL1RAB9ANPC1MEN1 | |
| SCHEMBL4044757 | 0.88 | MEN1 (0.48) | ALDH1A1L3MBTL1RAB9ANPC1MEN1 | |
| SCHEMBL4040460 | 0.88 | MEN1 (0.46) | ALDH1A1L3MBTL1RAB9ANPC1MEN1 | |
| SCHEMBL4044158 | 0.87 | GAA (0.47) | HPGDALDH1A1RAB9ALMNATSHR | |
| SCHEMBL4040899 | 0.87 | KDM4E (0.47) | HPGDALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL4037396 | 0.86 | METAP2 (0.46) | HPGDALDH1A1RAB9ALMNATSHR | |
| SCHEMBL4041730 | 0.83 | C3AR1 (0.46) | HPGDALDH1A1LMNANPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |