Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036690 | 0.85 | TSHR (0.43) | KMT2ATSHRHSD17B10HTTKDM4E | |
| SCHEMBL4044158 | 0.85 | GAA (0.47) | KMT2ATSHRHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL4039455 | 0.85 | KMT2A (0.48) | KMT2ATSHRHSD17B10HTTKDM4E | |
| SCHEMBL4044367 | 0.83 | PKM (0.40) | KMT2ATSHRHSD17B10HTTKDM4E | |
| SCHEMBL4042729 | 0.83 | HPGD (0.44) | KMT2ATSHRHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL4044939 | 0.83 | NPC1 (0.46) | KMT2ATSHRHSD17B10HTTKDM4E | |
| SCHEMBL4044888 | 0.82 | KMT2A (0.45) | KMT2ATSHRHSD17B10HTTKDM4E | |
| SCHEMBL4039869 | 0.82 | HPGD (0.45) | KMT2ATSHRALDH1A1MEN1HPGD | |
| SCHEMBL4043366 | 0.82 | TSHR (0.50) | KMT2ATSHRHSD17B10HTTKDM4E | |
| SCHEMBL4042940 | 0.81 | TSHR (0.45) | KMT2ATSHRHSD17B10HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |