Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032869 | 0.69 | POLB (0.46) | POLBSMN1; SMN2TSHRUSP2MAPT | |
| SCHEMBL1385963 | 0.67 | KMT2A (0.43) | POLBSMN1; SMN2NPSR1TSHRUSP2 | |
| SCHEMBL26673580 | 0.65 | ALDH1A1 (0.49) | SMN1; SMN2CYP2C19MEN1KMT2ALMNA | |
| SCHEMBL4169902 | 0.64 | GPBAR1 (0.69) | POLBSMN1; SMN2CYP3A4CYP2C19NPSR1 | |
| SCHEMBL31350913 | 0.64 | RXFP1 (0.71) | POLBSMN1; SMN2CYP3A4CYP2C19NPSR1 | |
| SCHEMBL4180101 | 0.64 | GPBAR1 (0.73) | POLBSMN1; SMN2CYP3A4CYP2C19NPSR1 | |
| SCHEMBL4187616 | 0.62 | POLB (0.52) | POLBSMN1; SMN2TSHRMAPTMEN1 | |
| SCHEMBL5085809 | 0.62 | TSHR (0.54) | POLBSMN1; SMN2TSHRMAPTMEN1 | |
| SCHEMBL3830421 | 0.62 | GPBAR1 (0.90) | POLBSMN1; SMN2CYP3A4CYP2C19NPSR1 | |
| SCHEMBL4184681 | 0.62 | GPBAR1 (0.90) | POLBSMN1; SMN2CYP3A4CYP2C19NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |