Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038201 | 0.83 | NPSR1 (0.49) | KMT2AMEN1GAAPOLBATM | |
| SCHEMBL4037007 | 0.83 | NPSR1 (0.49) | KMT2AMEN1GAAPOLBATM | |
| SCHEMBL4031104 | 0.83 | NPSR1 (0.49) | KMT2AMEN1GAAPOLBATM | |
| SCHEMBL4036403 | 0.75 | NPSR1 (0.45) | KMT2AMEN1GAAPOLBNPC1 | |
| SCHEMBL4037549 | 0.75 | NPSR1 (0.47) | KMT2AMEN1GAAPOLBNPC1 | |
| SCHEMBL4034797 | 0.73 | NPSR1 (0.45) | KMT2AMEN1GAAPOLBNPSR1 | |
| SCHEMBL4029082 | 0.73 | GAA (0.45) | KMT2AMEN1GAAPOLBMAPT | |
| SCHEMBL4028916 | 0.73 | GAA (0.45) | KMT2AMEN1GAAPOLBMAPT | |
| SCHEMBL4028127 | 0.73 | NPSR1 (0.45) | KMT2AMEN1GAAPOLBNPSR1 | |
| SCHEMBL4031683 | 0.72 | TRPA1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |