Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3916395 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2RECQLLMNAKMT2AMEN1 | |
| SCHEMBL3995879 | 0.87 | KMT2A (0.38) | KMT2AMEN1FAAH | |
| SCHEMBL4215816 | 0.86 | ACHE (0.34) | FAAH | |
| O-Tolylamine SCHEMBL3995891 | 0.85 | GAA (0.34) | KMT2AFAAH | |
| SCHEMBL1810683 | 0.84 | ACHE (0.36) | KMT2AMEN1FAAH | |
| SCHEMBL3994486 | 0.84 | MCHR1 (0.37) | KMT2AMEN1FAAH | |
| Dimethylamine SCHEMBL3987722 | 0.82 | ACHE (0.35) | KMT2A | |
| SCHEMBL1808129 | 0.80 | CHRM2 (0.42) | KMT2AMEN1 | |
| SCHEMBL4033395 | 0.80 | MCHR1 (0.36) | KMT2AMEN1FAAH | |
| SCHEMBL1808149 | 0.79 | DRD4 (0.39) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |