Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 1/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.52 |
| ▸ | OGA | O60502 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15844342 | 0.87 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2HTR2CEPHX2 | |
| SCHEMBL26154086 | 0.87 | ALDH1A1 (0.65) | ALDH1A1KCNH2MC4RP2RX7OGA | |
| SCHEMBL5534711 | 0.86 | HDAC6 (0.66) | ALDH1A1KCNH2P2RX7HDAC6USP2 | |
| SCHEMBL31414598 | 0.85 | KMT2A (0.62) | ALDH1A1SMN1; SMN2HTR2CEPHX2P2RX7 | |
| SCHEMBL4036835 | 0.85 | KMT2A (0.62) | ALDH1A1SMN1; SMN2HTR2CEPHX2P2RX7 | |
| SCHEMBL6861732 | 0.84 | HTR2C (0.62) | ALDH1A1SMN1; SMN2HTR2CKCNH2MC4R | |
| SCHEMBL21541003 | 0.84 | HTR2C (0.62) | ALDH1A1SMN1; SMN2HTR2CKCNH2MC4R | |
| SCHEMBL4037264 | 0.84 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2HTR2CUSP2HPGD | |
| Hydrochloric Acid SCHEMBL6479155 | 0.83 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2HTR2CUSP2HPGD | |
| SCHEMBL20811294 | 0.82 | HTR2C (0.62) | HTR2CKCNH2MC4RP2RX7HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501467-A4 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1501467-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | Bristol-Myers Squibb Company (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003088908-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-10-30 | — | — | WO | disclosed |