Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MLYCD | O95822 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31414598 | 1.00 | KMT2A (0.62) | KMT2ATSHRKDM4EP2RX7MEN1 | |
| SCHEMBL4000039 | 0.93 | HTR2C (0.61) | KMT2ATSHRKDM4EP2RX7MEN1 | |
| SCHEMBL5075663 | 0.92 | KMT2A (0.67) | KMT2ATSHRKDM4EP2RX7MEN1 | |
| SCHEMBL5526975 | 0.88 | KDM4E (0.65) | KMT2ATSHRKDM4EP2RX7MEN1 | |
| Formic Acid SCHEMBL5076802 | 0.87 | KMT2A (0.62) | KMT2ATSHRKDM4EP2RX7MEN1 | |
| SCHEMBL15844342 | 0.87 | ALDH1A1 (0.54) | KMT2ATSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4035356 | 0.85 | ALDH1A1 (0.64) | P2RX7HPGDALDH1A1SMN1; SMN2HTR2C | |
| SCHEMBL25156178 | 0.83 | ALDH1A1 (0.56) | KMT2ATSHRHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL29583269 | 0.83 | ALDH1A1 (0.56) | KMT2ATSHRHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL7314615 | 0.81 | HTR2C (0.60) | KMT2ATSHRKDM4EP2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501467-A4 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1501467-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | Bristol-Myers Squibb Company (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003088908-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-10-30 | — | — | WO | disclosed |