Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037167 | 0.91 | NOS1 (0.47) | KMT2AMEN1NPC1HSP90AA1ECE2 | |
| SCHEMBL27768647 | 0.81 | MEN1 (0.51) | KMT2AMEN1NPC1HSP90AA1ECE2 | |
| SCHEMBL22497090 | 0.81 | NOS1 (0.56) | KMT2AMEN1NOS1MTNR1AMTNR1B | |
| SCHEMBL30093244 | 0.81 | NOS1 (0.56) | KMT2AMEN1NOS1MTNR1AMTNR1B | |
| SCHEMBL4040211 | 0.79 | MEN1 (0.49) | KMT2AMEN1NPC1ECE2AGTR1 | |
| SCHEMBL27912688 | 0.74 | MAPT (0.66) | KMT2AMEN1MTNR1AMTNR1BKDM4E | |
| SCHEMBL12834058 | 0.74 | KDM4E (0.50) | KMT2AMEN1NPC1PDE10APDE4D | |
| SCHEMBL7586344 | 0.73 | MEN1 (0.48) | KMT2AMEN1NPC1HSP90AA1ECE2 | |
| SCHEMBL9071991 | 0.72 | KMT2A (0.52) | KMT2AMEN1NPC1HSP90AA1NOS1 | |
| SCHEMBL8516691 | 0.72 | PDE10A (0.52) | KMT2AMEN1NPC1HSP90AA1ECE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101611009-A | Quinoline derivatives | CHRONOGEN INC (US) | 2009-12-23 | — | — | CN | claimed |
| CN-101611009-A | Quinoline derivatives | CHRONOGEN INC (US) | 2009-12-23 | — | — | CN | disclosed |
| EP-2079699-A1 | QUINOLINE DERIVATIVES | Envivo Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |