Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.76 |
| ▸ | HTR1A | P08908 | 5/20 | 0.76 |
| ▸ | HTR2C | P28335 | 4/20 | 0.76 |
| ▸ | HTR2B | P41595 | 3/20 | 0.76 |
| ▸ | HTR6 | P50406 | 4/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.61 |
| ▸ | HRH1 | P35367 | 2/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.61 |
| ▸ | HTR1D | P28221 | 2/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | HTR1E | P28566 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30896267 | 0.86 | HTR2A (0.81) | HTR2AHTR1AHTR2CHTR2BHTR6 | |
| N,N-Dimethyltryptamine SCHEMBL29350959 | 0.86 | HTR2A (1.00) | HTR2AHTR1AHTR2CHTR2BHTR6 | |
| N,N-Dimethyltryptamine SCHEMBL27221709 | 0.86 | HTR2A (1.00) | HTR2AHTR1AHTR2CHTR2BHTR6 | |
| N,N-Dimethyltryptamine SCHEMBL335710 | 0.86 | HTR2A (1.00) | HTR2AHTR1AHTR2CHTR2BHTR6 | |
| N,N-Dimethyltryptamine SCHEMBL23069121 | 0.85 | HTR2A (0.97) | HTR2AHTR1AHTR2CHTR2BHTR6 | |
| N,N-Dimethyltryptamine SCHEMBL25285129 | 0.85 | HTR2A (0.97) | HTR2AHTR1AHTR2CHTR2BHTR6 | |
| SCHEMBL14950623 | 0.83 | HTR1A (0.76) | HTR2AHTR1AHTR2CHTR2BHTR6 | |
| SCHEMBL8861727 | 0.83 | HTR2A (0.76) | HTR2AHTR1AHTR2CHTR2BHTR6 | |
| SCHEMBL20970920 | 0.82 | HTR1A (0.74) | HTR2AHTR1AHTR2CHTR2BHTR6 | |
| SCHEMBL29504149 | 0.82 | HTR1A (0.74) | HTR2AHTR1AHTR2CHTR2BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611088-B1 | HYDROXAMATES AS THERAPEUTIC AGENTS | PHARMACYCLICS INC (US) | 2009-06-17 | — | — | EP | claimed |
| WO-2006069096-A1 | SILANOL DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2006-06-29 | — | — | WO | disclosed |