Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12685246 | 0.81 | PIM1 (0.57) | KMT2ATSHRMEN1HSD17B10PIM1 | |
| SCHEMBL9761124 | 0.72 | KMT2A (0.52) | KMT2ATSHRMEN1HSD17B10PIM1 | |
| SCHEMBL1759383 | 0.70 | PIM1 (1.00) | PIM1TP53 | |
| SCHEMBL30783861 | 0.69 | KMT2A (0.48) | KMT2ATSHRMEN1HSD17B10PIM1 | |
| SCHEMBL1707833 | 0.68 | ALDH1A1 (0.56) | KMT2AMEN1HSD17B10SMN1; SMN2TP53 | |
| SCHEMBL11855734 | 0.68 | GAA (0.56) | KMT2ATSHRMEN1HSD17B10SMN1; SMN2 | |
| SCHEMBL21914523 | 0.67 | PIM1 (0.49) | KMT2ATSHRMEN1HSD17B10PIM1 | |
| SCHEMBL22587289 | 0.66 | KMT2A (0.68) | KMT2ATSHRMEN1HSD17B10SMN1; SMN2 | |
| SCHEMBL19145306 | 0.65 | TP53 (0.64) | KMT2AMEN1HSD17B10SMN1; SMN2TP53 | |
| SCHEMBL30766045 | 0.65 | KMT2A (0.51) | KMT2ATSHRMEN1HSD17B10PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725544-B1 | 3-[4-HETEROCYCLYL-1,2,3-TRIAZOL-1-YL]-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM PHARMA (US) | 2009-05-27 | — | — | EP | disclosed |