Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.55 |
| ▸ | KDR | P35968 | 8/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.47 |
| ▸ | PAK4 | O96013 | 6/20 | 0.47 |
| ▸ | PLK4 | O00444 | 5/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | FER | P16591 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034572 | 0.89 | IGF1R (0.70) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4034569 | 0.83 | IGF1R (0.66) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL2122642 | 0.81 | IGF1R (0.72) | IGF1RFGFR1KDRINSR | |
| SCHEMBL2120422 | 0.78 | IGF1R (0.64) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL4037067 | 0.76 | IGF1R (0.69) | IGF1RFGFR1KDRINSR | |
| SCHEMBL2121059 | 0.75 | IGF1R (0.81) | IGF1RFGFR1KDRINSR | |
| SCHEMBL4033906 | 0.74 | IGF1R (0.79) | IGF1RFGFR1KDRINSRPAK4 | |
| SCHEMBL1807323 | 0.74 | NTRK1 (0.51) | IGF1RFGFR1KDRNTRK1PAK4 | |
| SCHEMBL3338511 | 0.74 | NTRK1 (0.57) | IGF1RFGFR1KDRNTRK1PAK4 | |
| SCHEMBL4034838 | 0.73 | IGF1R (0.78) | IGF1RFGFR1KDRNTRK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |
| CN-1289486-C | Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (igf-1) | ASTRAZENECA AB (SE) | 2006-12-13 | — | — | CN | disclosed |
| CN-1617858-A | Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (igf-1) | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | CN | disclosed |