SCHEMBL4036240

SCHEMBL4036240

O=C(NC1CCCCC1)C(C1CCCCC1)C1(c2cccc(OC(F)(F)F)c2)Nc2ccccc2N1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 2/20 0.43
EPHX2 P34913 2/20 0.43
TAS1R3 Q7RTX0 1/20 0.41
TAS1R1 Q7RTX1 1/20 0.41
TAS1R2 Q8TE23 1/20 0.41
METAP2 P50579 2/20 0.39
METAP1 P53582 1/20 0.39
FAAH O00519 1/20 0.38
ALDH1A1 P00352 1/20 0.38
RAB9A P51151 1/20 0.38
CETP P11597 1/20 0.38
PYGL P06737 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
BRD4 O60885 1/20 0.37
CREBBP Q92793 1/20 0.37
CHRM3 P20309 1/20 0.37
CXCR3 P49682 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4036803 0.90 L3MBTL1 (0.45) METAP2METAP1FAAHALDH1A1RAB9A
SCHEMBL4039200 0.88 PKM (0.50) EPHX1METAP2METAP1FAAHALDH1A1
SCHEMBL4038973 0.83 NPC1 (0.46) EPHX2ALDH1A1RAB9A
SCHEMBL4042940 0.83 TSHR (0.45) EPHX1EPHX2METAP2METAP1ALDH1A1
SCHEMBL4037171 0.83 NPC1 (0.47) EPHX2RAB9A
SCHEMBL4037071 0.81 EPHX1 (0.46) EPHX1METAP2METAP1FAAHALDH1A1
SCHEMBL4037602 0.81 EPHX1 (0.50) EPHX1METAP2METAP1FAAHALDH1A1
SCHEMBL4044228 0.80 TSHR (0.41) EPHX1ALDH1A1RAB9A
SCHEMBL4034657 0.80 SMN1; SMN2 (0.50) EPHX1RAB9AL3MBTL1
SCHEMBL4036471 0.80 SMN1; SMN2 (0.42) METAP2METAP1ALDH1A1RAB9AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2038259-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F.HOFFMANN-LA ROCHE AG (CH) 2009-03-25 EP disclosed
WO-2008000643-A1 BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME F. HOFFMANN-LA ROCHE AG (CH) 2008-01-03 WO disclosed