Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036613 | 0.77 | NOTUM (0.44) | SMN1; SMN2ALDH1A1HPGDL3MBTL1KDM4E | |
| SCHEMBL4035995 | 0.76 | IDO1 (0.49) | SMN1; SMN2ALDH1A1HPGDL3MBTL1KDM4E | |
| SCHEMBL4036284 | 0.75 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1HPGDL3MBTL1KDM4E | |
| SCHEMBL8280432 | 0.74 | CNR1 (0.48) | SMN1; SMN2ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL8279471 | 0.73 | CYP2C19 (0.33) | SMN1; SMN2ALDH1A1HPGDRAB9AMEN1 | |
| SCHEMBL14249281 | 0.67 | POLB (0.47) | ALDH1A1HPGDKDM4ENPC1RAB9A | |
| SCHEMBL14248954 | 0.64 | GRM5 (0.34) | SMN1; SMN2ALDH1A1HPGDL3MBTL1KDM4E | |
| SCHEMBL14248834 | 0.62 | TDP1 (0.48) | SMN1; SMN2ALDH1A1HPGDL3MBTL1KDM4E | |
| SCHEMBL15201380 | 0.62 | PREP (0.45) | RAB9AMAPK1 | |
| SCHEMBL7083262 | 0.61 | CTSA (0.45) | SMN1; SMN2ALDH1A1L3MBTL1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1722785-A4 | ION CHANNEL MODULATORS | WYETH CORP (US) | 2009-07-08 | — | — | EP | disclosed |
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070208064-A1 | Ion channel modulators | WYETH (US) | 2007-09-06 | — | — | US | disclosed |
| EP-1722785-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| EP-1723117-A2 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005087228-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |
| WO-2005086836-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281937-A1 | Ion Channel Modulators | CACNA1B, CACNA1C, TRPV1 | SMN1; SMN2 661/4885ALDH1A1 3706/4885HPGD 2634/4885 |
| US-20070208064-A1 | Ion channel modulators | CACNA1B, CACNA1C, TRPV1 | SMN1; SMN2 661/4885ALDH1A1 3706/4885HPGD 2634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.