Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14248954 | 0.88 | GRM5 (0.34) | SMN1; SMN2ALDH1A1CYP3A4CYP2C19NOTUM | |
| SCHEMBL8279471 | 0.81 | CYP2C19 (0.33) | SMN1; SMN2ALDH1A1CYP3A4CYP2C19NOTUM | |
| SCHEMBL4036613 | 0.80 | NOTUM (0.44) | SMN1; SMN2ALDH1A1CYP3A4CYP2C19NOTUM | |
| SCHEMBL4035995 | 0.77 | IDO1 (0.49) | SMN1; SMN2ALDH1A1CYP2C19MAPTGAA | |
| SCHEMBL4036279 | 0.75 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1CYP2C19MAPTKDM4E | |
| SCHEMBL14752938 | 0.70 | ALK (0.35) | ALDH1A1CYP2C19GAAPOLBCYP1A2 | |
| SCHEMBL8280432 | 0.69 | CNR1 (0.48) | SMN1; SMN2ALDH1A1MAPTGAAKMT2A | |
| SCHEMBL11929579 | 0.67 | TDP1 (0.40) | SMN1; SMN2ICAM1SELEALDH1A1MAPT | |
| SCHEMBL870352 | 0.67 | MLYCD (0.57) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL14249281 | 0.67 | POLB (0.47) | ALDH1A1MAPTGAAKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1722785-A4 | ION CHANNEL MODULATORS | WYETH CORP (US) | 2009-07-08 | — | — | EP | disclosed |
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070281937-A1 | Ion Channel Modulators | SCION PHARMACEUTICALS, INC. | 2007-12-06 | — | — | US | disclosed |
| US-20070208064-A1 | Ion channel modulators | WYETH (US) | 2007-09-06 | — | — | US | disclosed |
| EP-1722785-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| EP-1723117-A2 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005087228-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |
| WO-2005086836-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281937-A1 | Ion Channel Modulators | CACNA1B, CACNA1C, TRPV1 | SMN1; SMN2 661/4885ICAM1 3181/4885SELE 4724/4885 |
| US-20070208064-A1 | Ion channel modulators | CACNA1B, CACNA1C, TRPV1 | SMN1; SMN2 661/4885ICAM1 3181/4885SELE 4724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.