Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.40 |
| ▸ | SRC | P12931 | 6/20 | 0.40 |
| ▸ | LCK | P06239 | 12/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036111 | 0.95 | LCK (0.42) | FGFR1SRCLCKNUDT1 | |
| SCHEMBL4042434 | 0.81 | LCK (0.41) | FGFR1LCK | |
| SCHEMBL4042263 | 0.80 | LCK (0.47) | FGFR1SRCLCK | |
| SCHEMBL4044486 | 0.79 | LCK (0.38) | LCK | |
| SCHEMBL4037168 | 0.79 | MEN1 (0.44) | FGFR1LCK | |
| SCHEMBL4036362 | 0.78 | LCK (0.41) | FGFR1SRCLCKEGFR | |
| SCHEMBL7983561 | 0.78 | LCK (0.47) | LCK | |
| SCHEMBL7981390 | 0.78 | LCK (0.43) | FGFR1SRCLCKEGFRFGFR2 | |
| SCHEMBL4041190 | 0.76 | LCK (0.51) | FGFR1SRCLCKFGFR2FGFR4 | |
| SCHEMBL4040159 | 0.76 | LCK (0.38) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | claimed |
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | disclosed |