Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 17/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043849 | 0.94 | LCK (0.43) | LCKFGFR1SRCPIM1 | |
| SCHEMBL4038945 | 0.90 | LCK (0.50) | LCK | |
| SCHEMBL4042434 | 0.89 | LCK (0.41) | LCKFGFR1 | |
| SCHEMBL7979958 | 0.86 | LCK (0.56) | LCK | |
| SCHEMBL4036111 | 0.85 | LCK (0.42) | LCKFGFR1SRC | |
| SCHEMBL4044486 | 0.83 | LCK (0.38) | LCK | |
| SCHEMBL4041190 | 0.83 | LCK (0.51) | LCKFGFR1SRC | |
| SCHEMBL4037168 | 0.83 | MEN1 (0.44) | LCKFGFR1 | |
| SCHEMBL4038275 | 0.82 | LCK (0.40) | LCK | |
| SCHEMBL4038830 | 0.82 | LCK (0.49) | LCKFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | claimed |
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | disclosed |
| EP-2017273-A1 | Process for the enantioselective preparation of pregabalin | Laboratorios del Dr. Esteve S.A. (ES) | 2009-01-21 | — | — | EP | disclosed |