Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 3/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.41 |
| ▸ | NR0B2 | Q15466 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL403675 | 1.00 | HDAC11 (0.54) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL29920756 | 0.92 | HDAC11 (0.54) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL405279 | 0.88 | RARB (0.64) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL405278 | 0.88 | RARB (0.64) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL10046574 | 0.86 | HDAC11 (0.47) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL405400 | 0.81 | RARB (0.42) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL404023 | 0.80 | HDAC11 (0.76) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL30015150 | 0.80 | HDAC11 (0.76) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL404024 | 0.80 | HDAC11 (0.76) | HDAC11HDAC2HDAC7HDAC8HDAC6 | |
| SCHEMBL3292201 | 0.80 | HDAC6 (0.66) | HDAC11HDAC2HDAC7HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100330200-A1 | COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2010-12-30 | — | — | US | claimed |
| EP-2101820-A2 | COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2009-09-23 | — | — | EP | claimed |
| WO-2008077772-A2 | COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SPA (IT) | 2008-07-03 | — | — | WO | claimed |
| US-8101793-B2 | Anticarcinogenic and antimetastasis agents; leukemia or Hodgkin's disease. | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2012-01-24 | — | — | US | disclosed |
| US-20100330200-A1 | COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2010-12-30 | — | — | US | disclosed |
| EP-1412317-B1 | RETINOID DERIVATIVES WITH ANTIANGIOGENIC, ANTITUMOR AND PROAPOPTOTIC ACTIVITIES | SIGMA TAU IND FARMACEUTI (IT) | 2010-12-22 | — | — | EP | disclosed |
| EP-2101820-A2 | COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2009-09-23 | — | — | EP | disclosed |
| US-7449495-B2 | Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-11-11 | — | — | US | disclosed |
| WO-2008077772-A2 | COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SPA (IT) | 2008-07-03 | — | — | WO | disclosed |
| US-20080021088-A1 | Retinoid Derivatives With Antiangiogenic, Antitumoral And Proapoptotic Activities | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-01-24 | — | — | US | disclosed |
| US-20040235757-A1 | Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-11-25 | — | — | US | disclosed |
| EP-1412317-A1 | RETINOID DERIVATIVES WITH ANTIANGIOGENIC, ANTITUMOR AND PROAPOPTOTIC ACTIVITIES | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003011808-A1 | RETINOID DERIVATIVES WITH ANTIANGIOGENIC, ANTITUMORAL AND PROAPOPTOTIC ACTIVITIES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021088-A1 | Retinoid Derivatives With Antiangiogenic, Antitumoral And Proapoptotic Activities | RARA, RARB, RXRA | HDAC11 741/4885HDAC2 2349/4885HDAC7 813/4885 |
| US-20040235757-A1 | Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities | RARA, RARB, RARG | HDAC11 883/4885HDAC2 2621/4885HDAC7 1007/4885 |
| US-20100330200-A1 | COMBINATION OF A RETINOID AND A PLATINUM ANTICANCER AGENT | CXCR4, RARA, CXCL12 | HDAC11 1919/4885HDAC2 3081/4885HDAC7 1745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.