Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043634 | 0.95 | CTSD (0.42) | CTSDALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL4043642 | 0.93 | CTSD (0.46) | CTSDALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL4038953 | 0.90 | HCRTR1 (0.43) | CTSDALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL4044341 | 0.84 | C5AR1 (0.40) | CTSDALDH1A1MEN1KMT2AHDAC3 | |
| SCHEMBL4036919 | 0.82 | CNR1 (0.38) | CTSDALDH1A1PTPN1 | |
| SCHEMBL4040091 | 0.77 | LMNA (0.40) | CTSDLMNAMEN1KMT2APAX8 | |
| SCHEMBL4035711 | 0.77 | TSHR (0.42) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL4043117 | 0.70 | MEN1 (0.46) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL4039895 | 0.70 | GAA (0.41) | ALDH1A1LMNAMEN1KMT2AKDM4E | |
| SCHEMBL4043313 | 0.70 | TSHR (0.38) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |