Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004955 | 0.65 | GDA (0.49) | GDARPS6KA3BLMTDP1ADORA2B | |
| SCHEMBL18989874 | 0.64 | GDA (0.47) | GDARPS6KA3BLMTDP1ADORA2B | |
| SCHEMBL5518489 | 0.61 | GDA (0.62) | GDABLMTDP1ADORA2BKDM4E | |
| Uric Acid SCHEMBL2786719 | 0.61 | MAPT (0.53) | GDARPS6KA3BLMTDP1ADORA2B | |
| SCHEMBL1681856 | 0.61 | GDA (0.44) | GDARPS6KA3BLMTDP1ADORA2B | |
| SCHEMBL21389576 | 0.61 | GDA (0.40) | GDATDP1KDM4EALDH1A1DPP4 | |
| SCHEMBL31715084 | 0.61 | POLB (0.42) | GDATDP1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL4869377 | 0.60 | KDM4E (0.55) | GDABLMTDP1ADORA2BKDM4E | |
| SCHEMBL16495784 | 0.60 | GDA (0.39) | GDARPS6KA3BLMTDP1ADORA2B | |
| SCHEMBL7004643 | 0.60 | GDA (0.39) | GDARPS6KA3BLMTDP1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601673-B1 | FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-06-10 | — | — | EP | claimed |
| EP-1230243-B1 | POYCYLOALKYLPURINES AS ADENOSINE RECEPTOR ANTAGONISTS | BIOGEN IDEC INC (US) | 2009-03-04 | — | — | EP | claimed |