Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.32 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31715084 | 0.66 | POLB (0.42) | GDADPP4TDP1KDM4EALDH1A1 | |
| SCHEMBL30423047 | 0.64 | KDM4E (0.39) | GDADPP4TDP1KDM4EMAPT | |
| SCHEMBL31714747 | 0.62 | TYMP (0.38) | GDADPP4ALDH1A1RAB9AHSD17B10 | |
| SCHEMBL7004955 | 0.60 | GDA (0.49) | GDADPP4BLMTDP1ADORA2B | |
| SCHEMBL4037097 | 0.60 | GDA (0.41) | GDADPP4BLMTDP1ADORA2B | |
| SCHEMBL1681856 | 0.59 | GDA (0.44) | GDADPP4BLMTDP1ADORA2B | |
| SCHEMBL7018998 | 0.59 | RAB9A (0.32) | KDM4ERAB9A | |
| SCHEMBL18989874 | 0.59 | GDA (0.47) | GDADPP4BLMTDP1ADORA2B | |
| SCHEMBL16495784 | 0.58 | GDA (0.39) | GDADPP4BLMTDP1ADORA2B | |
| SCHEMBL10778633 | 0.58 | GDA (0.42) | GDADPP4BLMTDP1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1347976-A2 | TRICYCLIC PURINE COMPOUNDS AND THEIR ANALOGS AS INHIBIOTRS OF CYTOKINE SIGNALLING | CELL THERAPEUTICS, INC. (US) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002068421-A2 | TRICYCLIC COMPOUNDS AND THEIR ANALOGS AS INHIBITORS OF CYTOKINE SIGNALING | CELL THERAPEUTICS, INC. (US) | 2002-09-06 | — | — | WO | disclosed |