Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.46 |
| ▸ | IGF1R | P08069 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | PAK4 | O96013 | 2/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | STAT5A | P42229 | 1/20 | 0.44 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770945 | 0.89 | FGFR1 (0.46) | FGFR1IGF1RKDRNTRK1JAK2 | |
| SCHEMBL4034896 | 0.87 | IGF1R (0.60) | FGFR1IGF1RKDRINSRJAK2 | |
| SCHEMBL218642 | 0.82 | MEN1 (0.62) | FGFR1IGF1RKDRINSRNTRK1 | |
| SCHEMBL4076750 | 0.80 | IGF1R (0.40) | FGFR1IGF1RKDRNTRK1JAK2 | |
| SCHEMBL3856477 | 0.79 | GRK6 (0.45) | FGFR1IGF1RKDRNTRK1JAK2 | |
| SCHEMBL4073779 | 0.79 | IGF1R (0.42) | FGFR1IGF1RKDRNTRK1JAK2 | |
| SCHEMBL2120951 | 0.78 | NTRK1 (0.58) | FGFR1IGF1RKDRNTRK1JAK2 | |
| SCHEMBL4010728 | 0.77 | FGFR1 (0.44) | FGFR1IGF1RKDRINSRAURKA | |
| SCHEMBL4031791 | 0.77 | IGF1R (0.79) | FGFR1IGF1RKDRINSRNTRK1 | |
| SCHEMBL4037330 | 0.77 | IGF1R (0.67) | FGFR1IGF1RKDRINSRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131463-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-05-21 | — | — | US | disclosed |
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131463-A1 | NOVEL COMPOUNDS | C1R, TBXA2R, F12 | FGFR1 1251/4885IGF1R 1655/4885KDR 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.