Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 17/20 | 0.54 |
| ▸ | CTSL | P07711 | 16/20 | 0.54 |
| ▸ | CTSS | P25774 | 15/20 | 0.54 |
| ▸ | CTSB | P07858 | 7/20 | 0.54 |
| ▸ | CTSV | O60911 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL461847 | 1.00 | CTSK (0.54) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5096789 | 0.89 | CTSK (0.56) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5096782 | 0.89 | CTSK (0.56) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL29590366 | 0.89 | CTSL (0.48) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL14342619 | 0.89 | CTSL (0.48) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5581546 | 0.89 | CTSL (0.48) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5105990 | 0.86 | CTSK (0.55) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5105986 | 0.86 | CTSK (0.55) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5099597 | 0.85 | CTSK (0.54) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5099601 | 0.85 | CTSK (0.54) | CTSKCTSLCTSSCTSBCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796677-A4 | METHOD FOR ACTIVATING TRPV4 CHANNEL RECEPTORS BY AGONISTS | SMITHKLINE BEECHAM CORP (US) | 2009-07-08 | — | — | EP | claimed |
| EP-1796677-A2 | METHOD FOR ACTIVATING TRPV4 CHANNEL RECEPTORS BY AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-20 | — | — | EP | claimed |
| WO-2006029209-A2 | METHOD FOR ACTIVATING TRPV4 CHANNEL RECEPTORS BY AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-16 | — | — | WO | claimed |
| US-20200085767-A1 | Methods for Treating Hydrocephalus | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2020-03-19 | — | — | US | disclosed |
| WO-2018119356-A1 | METHODS FOR TREATING HYDROCEPHALUS | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2018-06-28 | — | — | WO | disclosed |