Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 8/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039305 | 0.83 | MAPT (0.57) | RAB9AMEN1KMT2AGAATDP1 | |
| SCHEMBL4035224 | 0.83 | MAPT (0.57) | RAB9AMEN1KMT2AGAATDP1 | |
| SCHEMBL4749975 | 0.81 | MEN1 (0.60) | RAB9AMEN1KMT2ANPC1GAA | |
| SCHEMBL26343455 | 0.78 | SMARCA2 (0.52) | RAB9AMEN1KMT2ANPC1GAA | |
| SCHEMBL4035077 | 0.78 | LCK (0.52) | RAB9AMEN1KMT2AGFERNPC1 | |
| SCHEMBL16236545 | 0.78 | KMT2A (0.67) | RAB9AMEN1KMT2ANPC1TDP1 | |
| SCHEMBL30851500 | 0.75 | RAB9A (0.79) | RAB9AMEN1KMT2ANPC1MTOR | |
| SCHEMBL27193042 | 0.75 | RAB9A (0.79) | RAB9AMEN1KMT2ANPC1MTOR | |
| SCHEMBL12049693 | 0.75 | IDH1 (0.54) | RAB9AMEN1KMT2ANPC1GAA | |
| SCHEMBL17818385 | 0.73 | MEN1 (0.71) | RAB9AMEN1KMT2ANPC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100536-A1 | INHIBITORS OF KINASE ACTIVITY WITH 1,2-DI-CYCLYL SUBSTITUTED ALKYNE STRUCTURES | METHYLGENE INC. (CA) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009100536-A1 | INHIBITORS OF KINASE ACTIVITY WITH 1,2-DI-CYCLYL SUBSTITUTED ALKYNE STRUCTURES | METHYLGENE INC. (CA) | 2009-08-20 | — | — | WO | disclosed |