Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.40 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3916860 | 0.87 | MEN1 (0.42) | KMT2AMEN1LMNAHTTRECQL | |
| SCHEMBL3916126 | 0.84 | HRH3 (0.47) | KMT2AMEN1LMNAHTTRECQL | |
| SCHEMBL2942653 | 0.84 | HPGD (0.42) | KMT2AMEN1LMNAHTTPKM | |
| SCHEMBL5666076 | 0.81 | KMT2A (0.48) | KMT2AMEN1LMNAHTTRECQL | |
| SCHEMBL2932813 | 0.77 | MEN1 (0.43) | KMT2AMEN1LMNAHTTSMN1; SMN2 | |
| SCHEMBL4036584 | 0.77 | USP2 (0.49) | LMNASMN1; SMN2FAAH | |
| SCHEMBL2943001 | 0.76 | MEN1 (0.39) | KMT2AMEN1OPRK1 | |
| SCHEMBL4035704 | 0.75 | NPFFR1 (0.38) | KMT2AMEN1SMN1; SMN2NPFFR1NPFFR2 | |
| SCHEMBL2938912 | 0.75 | CYP3A4 (0.42) | KMT2AMEN1LMNARECQLSMN1; SMN2 | |
| SCHEMBL2941205 | 0.75 | MEN1 (0.44) | KMT2AMEN1LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |