Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2934834 | 0.88 | NPC1 (0.48) | HPGDLMNAMAPTALDH1A1GAA | |
| SCHEMBL2943001 | 0.87 | MEN1 (0.39) | KMT2AMEN1GAATSHR | |
| SCHEMBL2941530 | 0.87 | HPGD (0.43) | HPGDHTR1AKMT2APOLBMEN1 | |
| SCHEMBL2940005 | 0.85 | MGLL (0.43) | HPGDKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL4037689 | 0.84 | KMT2A (0.46) | KMT2AMEN1LMNAPKMHTT | |
| SCHEMBL2942520 | 0.83 | CYP3A4 (0.58) | HPGDPOLBLMNAALDH1A1GAA | |
| SCHEMBL2940506 | 0.83 | CYP3A4 (0.40) | KMT2AALDH1A1GAATSHR | |
| SCHEMBL1801910 | 0.83 | KMT2A (0.44) | HPGDHTR1AKMT2APOLBMEN1 | |
| SCHEMBL2940806 | 0.83 | CA1 (0.56) | — | |
| SCHEMBL2943099 | 0.82 | CRBN (0.47) | KMT2APOLBMAPTHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730147-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2010-02-03 | — | — | EP | claimed |