Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30080659 | 1.00 | KMT2A (0.68) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL4035224 | 0.91 | MAPT (0.57) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL4039305 | 0.91 | MAPT (0.57) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL5444452 | 0.90 | BAZ1A (0.66) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL4219457 | 0.90 | MAPT (0.71) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL5597699 | 0.86 | KMT2A (0.90) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL4749975 | 0.86 | MEN1 (0.60) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL30101230 | 0.86 | KMT2A (0.90) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL17936093 | 0.85 | MAPT (0.74) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL17818404 | 0.85 | MAPT (0.70) | KMT2AMAPTMEN1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266537-B2 | 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof | St. Chuan University (CN) | 2019-04-23 | — | — | US | disclosed |
| US-10266537-B2 | 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof | St. Chuan University (CN) | 2019-04-23 | — | — | US | disclosed |
| EP-3246327-A1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | Si Chuan University (CN) | 2017-11-22 | — | — | EP | disclosed |
| US-20170305920-A1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | SI CHUAN UNIVERSITY (CN) | 2017-10-26 | — | — | US | disclosed |
| US-20170305920-A1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | SI CHUAN UNIVERSITY (CN) | 2017-10-26 | — | — | US | disclosed |
| WO-2016112846-A1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | 四川大学 | 2016-07-21 | — | — | WO | disclosed |
| WO-2009100536-A1 | INHIBITORS OF KINASE ACTIVITY WITH 1,2-DI-CYCLYL SUBSTITUTED ALKYNE STRUCTURES | METHYLGENE INC. (CA) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009100536-A1 | INHIBITORS OF KINASE ACTIVITY WITH 1,2-DI-CYCLYL SUBSTITUTED ALKYNE STRUCTURES | METHYLGENE INC. (CA) | 2009-08-20 | — | — | WO | disclosed |
| EP-2051710-A2 | COMPOSITIONS AND METHODS FOR TREATING, REDUCING, AMELIORATING, OR ALLEVIATING POSTERIOR-SEGMENT OPHTHALMIC DISEASES | Bausch & Lomb Incorporated (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008021729-A2 | COMPOSITIONS AND METHODS FOR TREATING, REDUCING, AMELIORATING, OR ALLEVIATING POSTERIOR-SEGMENT OPHTHALMIC DISEASES | BAUSCH & LOMB INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305920-A1 | 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF | DPYD, TYMP, WEE1 | KMT2A 3206/4885MAPT 4218/4885MEN1 1370/4885 |
| US-10266537-B2 | 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof | DPYD, TYMP, WEE1 | KMT2A 3206/4885MAPT 4218/4885MEN1 1370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.