Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 4/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 9/20 | 0.48 |
| ▸ | PAK3 | O75914 | 8/20 | 0.48 |
| ▸ | PAK2 | Q13177 | 8/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3339415 | 0.82 | IGF1R (0.66) | IGF1RKDRFGFR1AURKAAURKB | |
| SCHEMBL15071041 | 0.79 | PAK1 (0.75) | ITKIGF1RKDRFGFR1JAK2 | |
| SCHEMBL15209288 | 0.75 | PAK1 (0.72) | ITKIGF1RKDRFGFR1PAK1 | |
| SCHEMBL15208657 | 0.75 | PAK1 (0.61) | ITKIGF1RKDRFGFR1AURKA | |
| SCHEMBL16534531 | 0.74 | ITK (0.60) | ITKIGF1RKDRFGFR1AURKA | |
| SCHEMBL29683717 | 0.74 | ITK (0.60) | ITKIGF1RKDRFGFR1AURKA | |
| SCHEMBL30230471 | 0.72 | ITK (0.65) | ITKIGF1RKDRFGFR1AURKA | |
| SCHEMBL18154707 | 0.72 | ITK (0.65) | ITKIGF1RKDRFGFR1AURKA | |
| SCHEMBL22535808 | 0.71 | NTRK1 (0.55) | IGF1RJAK2PAK1PAK3PAK2 | |
| SCHEMBL588686 | 0.71 | JAK3 (0.68) | IGF1RFGFR1AURKAAURKBJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-B1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2009-03-11 | — | — | EP | disclosed |